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Physical Chemistry Chemical Physics

NMR Probing and Visualization of Correlated Structural Fluctuations in Intrinsically Disordered Proteins

Authors: Dennis Kurzbach; Andreas Beier; Agathe Vanas; Andrea Gabriele Flamm; Gerald Platzer; Thomas Schwarz; Robert Konrat

Publication Date: -0001-11-30  Article ASAP

A novel statistical analysis of paramagnetic relaxation enhancement (PRE) and paramagnetic relaxation interference (PRI) based nuclear magnetic resonance (NMR) data is proposed based on computation of correlation matrices. The technique is demonstrated with an example to the intrinsically disordered protein (IDP) Osteopontin (OPN) and the brain acid soluble protein 1 (BASP1). The correlation analysis visualizes in detail the subtleties of conformational averaging in IDPs and highlights the presence of correlated structural fluctuations of individual sub-domains in IDPs.  Read more